Sravanti Uppaluri

Areas of Interest & Expertise

Biophysics And Quantitative Biology, Modelling Biological Systems, Systems Biology: Evolutionary And Developmental Biology, Host-Pathogen Interactions, Genetic Circuits, Gene Regulation, Soft Condensed Matter , Microfluidics, Rheology Of Soft And Biological Matter, Protein Assembly, Biopolymer Dynamics , Cellular Organization, Growth And Size Control, Developmental Biology, Cell Motility

Biography

Sravanti is a faculty with the School of Arts and Sciences.

Her training and research background span biology, bioengineering and biophysics. Her undergraduate education was in biology at the McMaster University, Canada. Subsequently, she completed a Master’s in Bioengineering (genetic circuits) at the University of Toronto. 

During her PhD at the Max Planck Institute for Dynamics and Self-Organization, Goettingen, Germany, she used ideas and tools from soft condensed matter physics to understand the motility and rheology of unicellular parasites. Following which, she performed research at Princeton University as a postdoctoral fellow in developmental biology. 

She works primarily with undergraduate students to pursue questions that are broadly in the areas of developmental and regenerative biology. They conduct experiments to ask how organisms establish a body plan by cell sorting, what kinds of environments promote growth and regeneration and how interspecies interactions influence individual development and populations. 

Courses

Publications

Journal Articles

  • Shivers J, Uppaluri S, Brangwynne CP, Microfluidic immobilization and subcellular imaging of developing Caenorhabditis elegans. Microfluidics and Nanofluidics, (in Press) 2017 **Work with Undergraduate Mentee 
  • Thutupalli S*, Uppaluri S*, Constable G, Levin S, Stone H, Tarnita C, Brangwynne CP, Farming and Public Goods Production in C elegans, PNAS 114(9):2289 – 2294, 2017 *Equal contribution
  • Uppaluri S, Weber, SC, and Brangwynne, CP. Hierarchical size scaling during multicellular growth and development, Cell Reports, Cell Reports, 345(17), 2016
  • Uppaluri S, Brangwynne CP. A size threshold governs Caenorhabditis elegans developmental progression. Proceedings of the Royal Society B. 282: 201512832015.
  • Gilpin W, Uppaluri S, Brangwynne CP. Worms under pressure: bulk mechanical properties of C. elegans are independent of the cuticle. Biophysical Journal. 108(8):1887- 98. Apr 21, 2015 **Work with Undergraduate Mentee
  • Hochstetter A, Stellamanns E, Deshpande S, Uppaluri S, Engstler M, Pfohl T, Microfluidics-based single cell analysis reveals drug-dependent motility changes in trypanosomes. Lab Chip (15):1961 – 19682015
  • Stellamanns E, Uppaluri S, Hochstetter A, Heddergott N, Engstler M, Pfohl T. Optical trapping reveals propulsion forces, power generation and motility efficiency of the unicellular parasites Trypanosoma brucei brucei”. Scientific Reports 4(6515), Oct 12014.
  • Heddergott N, Krueger N, Wei A, Stellamanns E, Uppaluri S, Pfohl T, Engstler M. Trypanosome Motion Represents an Adaptation to the Crowded Environment of the Vertebrate Bloodstream. PLoS Pathogens 8(11): e10030232012.
  • Uppaluri S, Heddergott N, Stellamanns E, Herminghaus S, Engstler M, Pfohl T. Flow loading induces oscillatory trajectories in bloodstream parasites. Biophysical Journal. 103(6):1162 – 9 Sep 192012.
  • Uppaluri S, Nagler J, Stellamanns E, Heddergott N, Herminghaus S, Engstler M, Pfohl T. Impact of microscopic motility on the swimming behaviour of parasites: stiffer trypanosomes are more directional. PLoS Computational Biology, 7(6): e1002058, 2011. Featured article
  • Zaburdaev V, Uppaluri S, Friedrich R, Engstler M, Pfohl T, Stark H, Langevin dynamics deciphers the motility pattern of swimming parasites”. Physical Review Letters, vol. 106, no. 20, p. 208103, May 2011.

Book Chapter

Engstler M, Heddergott N, Krger T, Stellamanns E, Uppaluri S, Pfohl T. African Trypanosomes Are A Model System For Functional Analysis Of Microbial Motility in Nature Inspired Fluid Mechanics, edited by C.Tropea and H Bleckmann, Notes on Numerical Fluid Mechanics and Multidisciplinary Design (NNFM) 119, 43 – 612012.