Antara Das
Areas of Interest & Expertise
- Ion channels
- Epilepsy
- Circadian rhythms and sleep
Biography
Antara is a neurobiologist interested in studying how genetic mutations in ion channels leads to electrical imbalance in the brain, resulting in brain disorders such as epilepsy. Epilepsy affects about 1% of the world’s population including ~12 lakhs of people in India with active epilepsy. Epilepsy mutations can give rise to diverse clinical phenotypes and there is no cure for the disorder as yet.
She works with genetically amenable Drosophila melanogaster (commonly known as fruit-flies) as a model system to study epilepsy causing mutations. I am interested in understanding the cellular mechanism underlying seizure generation, and behavioural co-morbidities associated with epilepsy such as sleep disorders. The broad aim of her research is to evaluate how misfiring of neurons causes epileptic seizures and help to develop anti-epileptic therapies.
She graduated with a PhD from JNCASR, Bangalore, studying the role of temperature-sensitive TRPA1 ion channels in synchronising the circadian clock circuit to external time cues in Drosophila melanogaster. Most recently, she worked as a postdoc research scholar at University of California, Irvine (UCI), USA. She employed brain slice electrophysiology, imaging, and behaviour assays to characterize seizure behaviour and neuronal firing patterns in CRISPR generated mouse models of genetic epilepsy. I won the Trainee Professional Development Award (TPDA) from Society for Neuroscience (SfN) in Jan 2021, and have been offered membership to American Association for the Advancement of Science (AAAS) via my previous department at School Of Medicine, UCI.
Courses
Introduction to Neuroscience
The course aims to provide a foundational platform for students to get a broad overview
of how the nervous system function, the key players, and pursue related areas of study
such as psychology, artificial intelligence and system neuroscience.Seminar
Emphasises the integrative nature of Modern Biology.
Introduction to Genetics
Explores the classic and modern trends in genetics as well as its applications.
Molecular Biology and Biochemistry
Learn about the molecular components of life, how they interact, and how we experiment with them.
Publications
Journal articles
- Joardar, M., Das, A., Chowdhury, N. R., Mridha, D., Das, J., De, A., … & Roychowdhury, T. (2022). Impact of treated drinking water on arsenicosis patients with continuous consumption of contaminated dietary foodstuffs: A longitudinal health effect study from arsenic prone area, West Bengal, India. Groundwater for Sustainable Development, 18, 100786.
- Das, A., Joardar, M., Chowdhury, N. R., Mridha, D., De, A., Majumder, S., … & Roychowdhury, T. (2023). Significance of the prime factors regulating arsenic toxicity and associated health risk: a hypothesis-based investigation in a critically exposed population of West Bengal, India. Environmental Geochemistry and Health, 45(6), 3423 – 3446.
- Chowdhury, N. R., Joardar, M., Das, A., Mridha, D., Majumder, S., Mondal, M., … & Roychowdhury, T. (2023). Appraisal of acute and chronic arsenic exposure in differently exposed school children with special reference to micronuclei formation in urine epithelial cells: a comparative study in West Bengal, India. Groundwater for Sustainable Development, 21, 100917.
- Das, A.*, Smith, M.A., and O’Dowd, D.K*.(2021). “A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy.” Journal of Visualized Experiments: JoVE, no. 173 (July 12, 2021). https://doi.org/10.3791/62846. (*co-corresponding author)
- Das, A., Zhu,B., Xie,Y., Zeng,L., Pham,A.T., Neumann, J.C., Safrina, O., Benavides, D., MacGregor, G.R., Schutte,S.S., Hunt, R.F., and O’Dowd, D.K. (2021, April). Interneuron Dysfunction in a New Mouse Model of SCN1A GEFS. ENeuro, 8(2). 0394−20.2021. https://doi.org/10.1523/ENEURO.0394 – 20.2021.
- Das, A., Zhu,B., Xie,Y., Zeng,L., Pham,A.T., Neumann, J.C., MacGregor, G.R., Schutte,S.S., Hunt, R.F., and O’Dowd, D.K. (2019, November 21). Interneuron Dysfunction in a New Knock-in Mouse Model of SCN1A GEFS+. Preprint. Neuroscience. https://doi.org/10.1101/849240.
- Das, A., Holmes, T.C., and Vasu, Sheeba. (2016, June). DTRPA1 in Non-Circadian Neurons Modulates Temperature-Dependent Rhythmic Activity in Drosophila Melanogaster. Journal of Biological Rhythms 31(3), 272 – 88. https://doi.org/10.1177/0748730415627037.
- Das, A., Holmes, T.C., and Vasu, Sheeba. (2015). “DTRPA1 Modulates Afternoon Peak of Activity of Fruit Flies Drosophila Melanogaster.” PloS One 10(7). e0134213. https://doi.org/10.1371/journal.pone.0134213.
- Das, S., Sen. M., Saha, C., Chakraborty, D., Das, A., Banerjee, M., and Seal, A. (2011, July). “Isolation and Expression Analysis of Partial Sequences of Heavy Metal Transporters from Brassica Juncea by Coupling High Throughput Cloning with a Molecular Fingerprinting Technique.” Planta 234(1), 139 – 56. https://doi.org/10.1007/s00425-011‑1376‑1.
Book Chapter
Das, Antara and Vasu, Sheeba. (2017) Temperature Input for Rhythmic Behaviours in Flies: The Role of Temperature-Sensitive Ion Channels. In Kumar V. (eds) Biological Timekeeping: Clocks, Rhythms and Behaviour. Springer, New Delhi. Pages 405 – 424. https://doi.org/10.1007/978 – 81-322‑3688-7_19